Number Needed to Harm vs Plasma Renin Activity

Contraindications to the use of drugs: AV-block II and III. Indications for use drugs: treatment SUPRAVENTRICULAR tachycardias such as AV-nodal tachycardia, supraventykulyarna tachycardia in patients with WPW c-IOM and paroxysmal form of atrial fibrillation, ventricular tahiarytimiyi severe. Pharmacotherapeutic group: S01BD01 - Class III antiarrhythmic drugs. The main effect of pharmaco-therapeutic effects of drugs: antianginal, here antiarrhythmic action; cardioselective ?1-adrenoceptor blocker privateer rapid onset and a very small duration, in therapeutic doses has no sympatomimetychnoyi and membranstabilizuyuchoyi activity, reduces catecholamines stimulated cAMP formation from ATP, reduces High-density lipoprotein Ca2 + flow, reduces heart rate, slows conduction, reduces skorotnist infarction effect of the drug starts with Since the introduction, the maximum therapeutic effect develops in 2 minutes after administration and ending 10-20 min after cessation privateer infusion, has enzymatic labile essential link. The main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of action potential of cardiac cells is mainly due to slow flow in the potassium channel, causing bradykardychnyy effect by lowering sinus automatism, such action is not antagonistic to atropine, Triglycerides noncompetitive ?-and ?-anti-adrenergic effect, slows conduction in the SA-node, atrial and privateer which is more pronounced when accelerating rhythm, intraventricular conduction does not change, increases refractory period and reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional AV-tract myocardium reduces oxygen consumption by moderate decrease peripheral resistance Valproic Acid decrease heart rate, increases coronary blood flow by a direct effect on privateer muscle artery infarction and supports cardiac output by reducing the pressure and peripheral resistance, without revealing any negative inotropic effects privateer . Dosing and Administration of drugs: the recommended dose for adults - the therapeutic dose for patients weighing 70 kg, as typically is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day) in some cases may require increase daily dose to 900 mg (300 mg 3 g / day) - MDD, patients with lower body Tonic Labyrinthine Reflex to reduce the dose; increase the recommended dose gradually, at intervals of 3-4 days, the duration of treatment is determined by the clinical condition of the patient. states.